Database : HANSEN Search on : DEGENERACAO NEURAL [Subject descriptor] References found : 12 [refine] Displaying: 1 .. 12   in format [Detailed]

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Id: 18389 Author: Rambukkana, Anura Title: Mycobacterium leprae-induced demyelination: a model for early nerve degeneration ..- Source: s.l; s.n; 2004. 7 p. ilus. Abstract: The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstratation of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration (AU). Descriptors: DOENCAS DESMIELINIZANTES/etiol DOENCAS DESMIELINIZANTES/imunol DOENCAS DESMIELINIZANTES/microbiol DOENCAS DESMIELINIZANTES/patol MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/patogen - DEGENERACAO NEURAL/etiol  DEGENERACAO NEURAL/patol  HANSENIASE/compl  HANSENIASE/imunol  HANSENIASE/microbiol  HANSENIASE/patol Limits: HUMANO Location: BR191.1; 09300/s

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Id: 13571 Author: Reichart, Peter Hannover Title: Die chirurgische Korrektur des Lagophthalmus bei Leprapatienten Surgical correction of lagophthalmos in leprosy patients- Source: s.l; s.n; 1976. 3 p. ilus. Abstract: Lepra, verursacht durch das von HANSEN 1873 entdeckte Mycobacterium leprae, manifestiert sich im Gesicht mit formtypischen klinischen Bildern.(AU). Descriptors: HANSENIASE/compl PARALISIA FACIAL/etiol DEGENERACAO NEURAL OFTALMOPATIAS/etiol OFTALMOPATIAS/cirurg Limits: HUMANO MASCULINO ADULTO MEIA-IDADE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01669/s

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Id: 13508 Author: Helander, I; Partanen, J Title: Dapsone-induced distal axonal degeneration of the motor neurons ..- Source: s.l; s.n; 1978. 4 p. . Abstract: Dapsone proved to be effective treatment in a patient who suffered from erthema elevatum diutinum. Serious neurological side effects, however, appeared. The basic mechanism appeared to be a distal axonal degeneration of the motor neurons. Sensory conduction studies were normal in five consecutive EMG examinations. A diagnosis of anemia pernicosa was also made bu the blood values returned to normal after starting B12-vitamin therapy. Penicous anemia seemed not be an etiological factor in the polyneuropathy of our patient because we were not able toshow any damage to the sensory axons.(AU). Descriptors: POLINEUROPATIAS/ind quim ERITEMA/quimioter AXÔNIOS/ef drogas NEURÔNIOS MOTORES/ef drogas DEGENERACAO NEURAL DAPSONA/admin DAPSONA/ef adv DAPSONA/uso terap Limits: RELATO DE CASO HUMANO FEMININO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00351

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Id: 13411 Author: Boddingius, J Title: Ultrastructural changes in blood vessels of peripheral nerves in leprosy neuropathy ..- Source: s.l; s.n; September 26, 1977. 19 p. ilus, tab. Abstract: The ultrastructure of blood vessels in endoperi and epineurium was studied in peripheral cutaneous nerve biopsies of 16 borderline (BB), borderline-lepromatous (BL) or lepromatous (LL) leprosy patients some of whom were in reversal reaction. Comparable vessels in nerve biopsies of control cases and vessels in skin lesion biopsies of the leprosy patients were also studied. Vascular changes were found in nerves of all the leprosy patients. The changes were pronounced in endoneurial vessels and affected 1. endothelial continuity and surface structure, 2. basement membranes od endothelium and pericytes, and 3. the vessel lumen. In addition, intra-endothelial (IE) Mycobacterium leprae were a feature in some of the patients. Gaps occurring between endothelial cells and plasma insudation both noticed in vessels of fascicles with early to very early neuropathy suggested extensive leakage which, in all propability, causes early nerve fibre damage. Luminal and abluminal endothelial protusions, which were frequently observed, may enhance transendothelial transposrt. Fenestrations and endothelial attenuation, possibly, lead to an increase in vascular permeability. Endothelial phagocytotic activity, particularly in small (epineural) arteries, appeared to be stimulated, possibly, by circulating M. Leprae. Basement membrane multilayering (a hyaline zone) was found peripherally to pericytes, as is the case in tuberculoid leprosy (Boddingus, 1976). In a number of patients, multilayering occurred also periendothelially. Perivascular zones, which are thought to initiate or aggravate neuropathological changes by impairment of diffusion of oxygen and nutrients or metabolites, were very wide in endoneurial vessels of patients in reversal reaction and this suggested an immunological aetiology. Partial or total vessel lumen occlusion, seen in advanced lepromatous neuropathy, most likely contributes to final nerve fibre degeneration and endoneurial fibrosis. M. leprae were found intra-endothelially in endoneurial vessels, though only fascicles with advanced neuropathy whereas bacilli were not seen in vessel lumina. By contrast, infascicles with realtively early neuropathy, solid (viable) bacilli were frequently encountered intra-axonally in myelinated fibres. This suggested thast, inmany instances, primary infiltration of M. leprae into nerve facicles may arise from intraaxonal..(AU). Descriptors: PERMEABILIDADE CAPILAR HANSENIASE/patol DEGENERACAO NEURAL NERVOS PERIFERICOS/patol DOENCAS DO SISTEMA NERVOSO PERIFERICO/patol FAGOCITOSE VASA NERVORUM/patol PELE/inerv Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00031/s

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Id: 13343 Author: Anthony, J; Vaidya, M. C; Dasgupta, A Title: Ultrastructure of nerve in erythema nodosum leprosum (ENL) ..- Source: s.l; s.n; 1979. 4 p. ilus. Abstract: Gross changes of myelinated fibres and Schwann cells at different degenerative stages were present in all five ENL nerve lesions. Besides these changes, infiltrating cells mainly macrophages, deposition of excessive collagen and perineurial vessel damage were also observed.(AU). Descriptors: CELULAS DE SCHWANN/ultraest ERITEMA NODOSO/patol HANSENIASE/patol DEGENERACAO NEURAL FIBRAS NERVOSAS MIELINIZADAS/ultraest - SISTEMA NERVOSO/ultraest  COLAGENO  ORELHA/inerv  MICROSCOPIA ELETRÔNICA  CELULAS SANGUINEAS Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01060/s

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Id: 13294 Author: Enna, Carl D; Jacobson, Robert R; Rausch, Robert O Title: Bone changes in leprosy: a correlation of clinical and radiographic features ..- Source: s.l; s.n; 1971. 12 p. ilus. Abstract: Characteristic bone lesions in leprosy affect the small bones of the face, hands, and feet. They are due directly to leprous infection imposed upon denervated tissues. The manifestations of leprous bone infection vary from the presence of bacilli in the bone to actual destruction. Distal absorption involves fingers and toes with the loss of digits. Combined absorption of lenght and width of bone often affects the metatarsophalangeal joints. Tarsal absorption patterns are determined by abnormal weight-bearing forces and infection.(AU). Descriptors: DEDOS DO PE/radiogr HANSENIASE/radiogr ARTROPATIAS/radiogr DEGENERACAO NEURAL DOENCAS DO SISTEMA NERVOSO/compl FERIMENTOS E LESOES/compl FRATURAS/radiogr DEFORMIDADES ADQUIRIDAS DO PE/radiogr DEDOS/radiogr - FACE/radiogr  DOENCAS OSSEAS/etiol  DOENCAS OSSEAS/radiogr Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00600/s

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Id: 13201 Author: Dayan, A. D; Sandbank, U Title: Pathology of ther peripheral nerves in leprosy: report of a case ..- Source: s.l; s.n; oct. 1970. 6 p. ilus, graf. Abstract: Peripheral nerve trunks were examined from a case of lepromatous leprosy. M. leprae was seen in the nerves in several types of cells. isolated nerve fibre preparations showed demyelinating lesions due to Schwann cell damage and complete nerve fibre degeneration. The causes of this mixed pattern of damage may involve both a direct effect of the bacilli on nerve fibres and various epiphenomena.(AU). Descriptors: DOENCAS DESMIELINIZANTES/patol HANSENIASE/patol NERVO FEMORAL/patol AUTOPSIA NERVOS PERIFERICOS/patol CELULAS DE SCHWANN NERVO CIATICO/patol DEGENERACAO NEURAL NERVO ULNAR/patol REGENERACAO NERVOSA Limits: HUMANO IDOSO MASCULINO Electronic Medium: http://www.ilsl.br Location: BR191.1; 02018/s

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Id: 13193 Author: Shetty, V. P; Mehta, L. N; Irani, P. F; Antia, N. H Title: Study of the evolution of nerve damage in leprosy. Part I--Lesions of the index branch of the radial cutaneous nerve in early leprosyStudy of evolution of nerve damage in leprosy. Part II--Observations on the index branch of the radial cutaneous nerve in contacts of leprosy ..- Source: s.l; s.n; jan. 1980. 14 p. tab, graf, ilus. Abstract: A total of six index finger branch of the radial cutaneous (IRC) nerves from three BL, two BB and one BT cases of leprosy, with less than 6 months history of disease were subjected for nerve conduction velocity (NCV) studies followed by biopsy. The biopsy was divided into three parts and subjected for light microscopy quantitative histology, electron-microscopy and fibre tease studies. The nerves revealed a slight reduction in NCV and a varying degree of segmental demyelination ranging from 10% to 35%. The earliest changes observed were the thickening and proliferation of Schwann cell processes of the unmyelinated fibres and degeneration of their axons regardless of the type of leprosy.(AU) A total of 35 contacts from 20 families of lepromatous index cases were screened clinically. All of them were subjected for nerve conduction velocity (NCV) studies of both left and right index branch of the radial cutaneous (IRC) nerve. Fifteen of these nerves were biopsied. Out of 15 IRC nerves biopsied 10 had slightly reduced average NCV values and 5 were normal. Four nerves out of 10 where average NCV was reduced and 1 nerve out of 5 where NCV was normal showed significant ultrastructural changes and higher percentage of segmental demyelination (10%--13%). There was a striking similarity between the changes seen in the IRC nerves of early cases of leprosy and of contacts.(AU). Descriptors: PELE/irrig FATORES DE TEMPO HANSENIASE/patol DEGENERACAO NEURAL FIBRAS NERVOSAS/ultraest CONDUCAO NERVOSA NERVO RADIAL/patol NERVO RADIAL/ultraest DEDOS/irrig HANSENIASE/diag HANSENIASE/genet CELULAS DE SCHWANN/ultraest Limits: MASCULINO FEMININO ADOLESCENTE ADULTO CRIANCA HUMANO MEIA-IDADE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01984/s

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Id: 12244 Author: Rambukkana, Anura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; May 2002. 5 p. ilus, graf. Descriptors: APOPTOSE AXONIOS AXONIOS LINFOCITOS B ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL CAMUNDONGOS KNOCKOUT MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL FIBRAS NERVOSAS MIELINIZADAS NEURONIOS CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN NERVO CIATICO NERVO CIATICO LINFOCITOS T CULTURA DE TECIDO Limits: ANIMAL Location: BR191.1; 08647/s

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Id: 11749 Author: Rambukkana, Amura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; 2002. 5 p. ilus. Descriptors: HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE AXONIOS AXONIOS ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS MACROFAGOS MUTAÇAO BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL - FIBRAS NERVOSAS MIELINIZADAS  NEURONIOS  CÉLULAS DE SCHWANN  CÉLULAS DE SCHWANN  NERVO CIATICO  NERVO CIATICO  LINFOCITOS T  CULTURA DE TECIDO Location: BR191.1; 08525/s

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Id: 11608 Author: Whitcher, John P; Srinivasan, M Title: Leprosy - a new look at an old disease ..- Source: s.l; s.n; 2000. 2 p. . Descriptors: HANSENIASE HANSENIASE LEPROSTATICOS CEGUEIRA CEGUEIRA QUIMIOTERAPIA COMBINADA MYCOBACTERIUM LEPRAE DEGENERAÇAO NEURAL Location: BR191.1; 08431/s

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Id: 9571 Author: Yajima, Mikihisa; Murata, Junzo; Yamada, Nobutaka; Asano, Goro Title: Ultrastructural observations of small blood vessels in leprosy patients ..- Source: s.l; s.n; 1991. 7 p. ilus, tab. Descriptors: HANSENIASE PELE DEGENERAÇAO NEURAL ENDOTÉLIO VASCULAR ENDOTÉLIO VASCULAR NERVOS PERIFÉRICOS Location: BR191.1; 06286/s

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